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The References' Caves You can find there some references about chronic pain and PPP.

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Old 01-02-2017, 07:06 PM   #1
Jo Bowyer
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Default The Grand Challenge in Cranial Pain—From Migraine to Cranial Neuralgias: Understanding Differences and Similarities to Advance Knowledge and Management

http://journal.frontiersin.org/artic...017.00019/full

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The field of primary headaches and cranial neuralgias has experienced in a relatively brief period a startling progress in expansion of knowledge (1, 2). This has allowed partial unraveling of the machinery involved in the occurrence of attacks and the identification of a set of mediators and genes that are likely to play a role. In the case of migraine, accumulated evidence has very recently led to the development of the first disease-specific prophylactic drug, the CGRP antibodies (3). In other cases, drugs available for indications different from pain, such as botulinum toxin or the antiepileptic drugs, have been tested with adapted protocols proving effective in chronic migraine and showing potential efficacy in other cranial pains, i.e., cluster headache, trigeminal neuralgia, and temporomandibular joint disorder (4, 5).

Notwithstanding the undeniable scientific advances, much research is still needed to fully understand and effectively treat primary headaches and cranial neuralgias. Open issues are manifold, spanning from pathophysiology to clinical aspects, and represent exciting challenges for future research.
The Challenge of Pathophysiological Components of Cranial Pain

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The trigeminovascular system has been implicated as the major sensory system that mediates primary and secondary headaches of intracranial origin. More recent is the discovery that sensory innervation of the calvarial periosteum overlying the dorsal parts of the frontal and parietal calvarial bones is supplied primarily by trigeminal neurons with cell bodies located mainly within the ophthalmic division of the trigeminal ganglion (6). Taken together with the limited knowledge about the functional anatomy of the neurovascular unit, these data call for more investigations aimed at unraveling the functional anatomy and the physiology of cranial pain.
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Old 27-02-2017, 09:32 AM   #2
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Default The notorious TMJ by Cody Weisbach

https://noijam.com/2017/02/27/the-notorious-tmj/

I enjoy seeing these patients, they need a lot of calming down and reassurance. Any trigeminal neuralgia is worrying to the person who is living with it.
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