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Neuro? Logical! Forum for all neuro-things => from neuron to brain...

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Old 05-05-2017, 04:09 PM   #1
Rick Carter
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Default Cannon and Rosenblueth's law of denervation:

Cannon and Rosenblueth's law of denervation:

When a unit is destroyed, in a series of efferent neurons, an increased irritability to chemical agents develops in the isolated structure or structures, the effect being maximal in the part directly denervated.

In other words, when a nerve is below par and is not functioning properly (neuropathy), it becomes supersensitive and will behave erratically. This principle is fundamental and universal, yet it is not at all well known or credited!

Cannon and Rosenblueth recognized four types of increased sensitivity: the amplitude of response is unchanged but its time-course is prolonged (super-duration of response); the threshold of the stimulating agent is lower than normal (hyperexcitability); lessened stimuli which do not have to exceed a threshold produce responses of normal amplitude (increased susceptibility); and, the capacity of the tissue to respond is augmented (superreactivity). They also demonstrated that supersensitivity can occur in many structures of the body including skeletal muscle, smooth muscle, spinal neurons, sympathetic ganglia, adrenal glands, sweat glands, and even brain cells. Furthermore, they showed that denervated structures overreact to a wide variety of chemical and physical inputs including stretch and pressure.


(C. Chan Gunn, Patrick Wall)
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