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Cell Signalling Biology Book ch.10

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  • Tip Cell Signalling Biology Book ch.10

    Cell Signalling Biology Michael J. Berridge Module 10 Neuronal Signalling
    Found this: biology of the nervous system (not the exact name of the book) chapter 10, it's detailed info on neuronal signalling etc. and cel biology. About 104 pages, with nice pictures.
    Things as memory consolidation, synaptic plasticity and much more are described.
    Open access

    Last edited by marcel; 11-06-2014, 01:41 AM.

    "Evolution is a tinkerer not an engineer" F.Jacob
    "Without imperfection neither you nor I would exist" Stephen Hawking

  • #2
    For anyone who don't know the author's name, Professor Sir Michael Berridge, FRS

    Here's a bit of info.

    From this website

    Shaw Laureate in Life Science and Medicine 2005:

    In September 2005 Professor Berridge was awarded the prestigious Shaw Prize, for his pioneering work in the field of cell signalling. His discovery of the key role that calcium plays in regulating cellular activity and orchestrating the complexities of cellular communication has given insight into some of the physiological processes behind medical conditions like hypertension, cardiac arrhythmia and heart failure, cancer and bipolar disorders such as manic depressive illness.

    Professor Berridge’s discovery of the molecule inositol trisphosphate (IP3), and its role in the calcium signalling pathway, was a major breakthrough in understanding how a cell translates chemical stimuli at its external surface into an intracellular chemical language that enables the cell to elicit a physiological response. These breakthroughs have had a profound influence on diverse areas of biomedical research such as cell proliferation, fertilisation, neural activity, memory and learning, metabolism and muscle contraction.

    The Shaw Prize, hailed as the Nobel Prize of the East, consists of three annual prizes in the fields of life science and medicine, astronomy and mathematical sciences, each bearing a monetary award of $1 million US dollars. This international accolade honours individuals who have achieved significant breakthroughs in academic and scientific research, and whose work has resulted in a positive and profound impact on mankind.

    International Awards:

    Professor Berridge’s ground-breaking research and leadership in the field have earned him a plethora of prestigious international awards, including: the Heineken Prize for Biochemistry and Biophysics; the Gairdner Foundation International Award for outstanding achievement in biomedical research; the King Faisal International Prize in Science; The Wolf Foundation Prize in Medicine; the Albert Lasker Medical Research Award; and the Louis Jeantet Prize in Medicine.


    Other honours include his election as Honorary Member of the Japanese Biochemical Society, the American Physiological Society and of the Society for Experimental Biology; as member of the Academia Europaea, EMBO and The Academy of Medical Sciences (London); and as Foreign Associate of the National Academy of Science (Washington).

    In the words of one of his colleagues, "Mike... has pioneered a field that now infiltrates almost every area of biology and he has served as a distinguished ambassador for all who work in Ca2+ signalling".
    Last edited by marcel; 11-06-2014, 10:39 AM.

    "Evolution is a tinkerer not an engineer" F.Jacob
    "Without imperfection neither you nor I would exist" Stephen Hawking


    • #3
      This is beautifully written and the diagrams are state of the art.

      the ‘inflammatory soup’ surrounding a wound
      Jo Bowyer
      Chartered Physiotherapist Registered Osteopath.
      "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi


      • #4
        I can't get past the mistake in the first sentence:
        The brain contains approximately one trillion (1012) neurons that are located in different brain regions.
        One trillion? Nope.
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        • #5
          The complete digital book of 12 chapters can be found by going to the website, I've provided a link above.

          There's a nice video "eureka moments" (just 8 minutes) if you go to their website (link above) you will see a link called "eureka moments" it's an interview, about the discovery of ip3, how do cell's translate an outside signal into inside actions.
          Last edited by marcel; 11-06-2014, 06:24 PM.

          "Evolution is a tinkerer not an engineer" F.Jacob
          "Without imperfection neither you nor I would exist" Stephen Hawking


          • #6
            Since there's some activity on Glial cells

            In module 7 also this is discussed

            Functional interactions between neurons and astrocytes at the tripartite synapse.

            For a long time, astrocytes were thought to play a secondary role in the brain by supporting neuronal activity by carrying out a number of essential housekeeping duties. They are known to provide neurons with nutrients and the redox buffer glutathione (GSH) (Module 12: Figure astrocyte-induced neuronal cell death). They provide a mechanisms for the spatial buffering of K+ and they remove neurotransmitters and other waste products. Recently, however, it has become apparent that glial cells play a much more active role in regulating neural function because they not only respond to information coming from the neurons, but also can transmit information back to the neurons. This two-way dialogue, which depends upon the neuronal–astrocyte communication and the reciprocal astrocyte–neuronal communication systems, may play a critical role in modulating neuronal activity and information processing in the brain. It is becoming evident that this active participation in brain function depends upon a process of astrocyte excitability . This excitability has two important functional consequences. First, it results in the formation of intra- and inter-cellular Ca2+ waves that spread information throughout individual cells or between groups of cells respectively. For example, this excitability is critical for the astrocyte regulation of cerebral blood flow , where astrocytes integrate the degree of neural activity and use this information to regulate contractile tone in arteriole smooth muscle cells. Secondly, astrocyte excitability can lead to the formation of spontaneous astrocyte Ca2+ oscillations that may have a critical role to play in the astrocyte–neuronal communication system. The complex astrocyte structure reveals the intimate associations with both neurons and blood vessels and shows how these cells can perform these different functions.

            The astrocytes appear to be particularly sensitive to the β-amyloid peptides and may contribute to the pathology of Alzheimer's disease through a process of astrocyte-induced neuronal death.

            Astrocyte structure

            The problem with trying to deal with astrocyte function is that astrocytes come in many different shapes and sizes (Module 7: Figure astrocyte diversity ). Some of these astrocytes have precise locations, such as the Bergmann glia (cell II in Module 7: Figure astrocyte diversity ) and the Müller cells found in the retina. These astrocytes are also defined by the kinds of connections that they make within the brain. For example, the tanycytes have their cell bodies facing the ventricles, and then have long extensions connecting to either the pia or the blood vessels. A characteristic feature of many of the astrocytes is a long extension with an endfoot that is attached to a blood vessel (e.g. cells Ib and IV–VII in Module 7: Figure astrocyte diversity ). It is this cell type that co-ordinates neural activity with cerebral blood flow.
            Last edited by marcel; 25-06-2014, 11:17 PM.

            "Evolution is a tinkerer not an engineer" F.Jacob
            "Without imperfection neither you nor I would exist" Stephen Hawking


            • #7
              Signaling Systems: Transferring information without distortion


              Despite employing diverse molecular mechanisms, many different cell signaling systems avoid losing information by transmitting it in a linear manner.
              Jo Bowyer
              Chartered Physiotherapist Registered Osteopath.
              "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi


              • #8
                Signaling pathways as linear transmitters


                Cells must continually sense, interpret, and respond to their environment. This is orchestrated by signaling pathways: networks of multiple proteins that transmit signals and initiate cellular response. Signaling pathways are critical to animal development and physiology, and yet there are fewer than 20 classes of metazoan signaling pathways (Gerhart, 1999). These signaling pathways evolved prior to the Cambrian and remain highly conserved across animal phyla (Gerhart, 1999; Pires-daSilva and Sommer, 2003). Each signaling pathway, therefore, governs a wide range of cellular events, both within and across organisms.
                Jo Bowyer
                Chartered Physiotherapist Registered Osteopath.
                "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi