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Premotor Symptoms as Predictors of Outcome in Parkinsons Disease: A Case-Control Study

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  • #61
    Exercise can improve non-motor symptoms of Parkinson's disease

    https://www.sciencedaily.com/release...0304105418.htm
    Jo Bowyer
    Chartered Physiotherapist Registered Osteopath.
    "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

    Comment


    • #62
      Virtual reality offers benefits for Parkinson's disease patients

      Training in virtual environment helps patients improve balance and avoid obstacles while walking

      https://www.sciencedaily.com/release...0409162815.htm
      Jo Bowyer
      Chartered Physiotherapist Registered Osteopath.
      "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

      Comment


      • #63
        Voluntary and spontaneous facial mimicry toward other’s emotional expression in patients with Parkinson’s disease

        https://journals.plos.org/plosone/ar...l.pone.0214957
        Jo Bowyer
        Chartered Physiotherapist Registered Osteopath.
        "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

        Comment


        • #64
          Impulse control disorders in Parkinson’s disease: A systematic review on the psychometric properties of the existing measures

          https://journals.plos.org/plosone/ar...l.pone.0217700

          A significant percentage of patients suffering from Parkinson’s Disease (PD) experience Impulse Control Disorders (ICDs), contributing to reduced quality of life. As they can be managed by reducing the dopamine dosage, the detection of their presence is crucial for PD treatment plan. Nevertheless, they tend to be under-recognized in clinical practice, since routine screening is not common–despite existing instruments that may support clinicians. This work presents a systematic review on the psychometric properties of instruments measuring ICDs in PD, to test whether clinicians dispose of valid tools that may help them in clinical assessment.
          Jo Bowyer
          Chartered Physiotherapist Registered Osteopath.
          "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

          Comment


          • #65
            The burden of care and the understanding of disease in Parkinson’s disease

            https://journals.plos.org/plosone/ar...l.pone.0217581

            Parkinson's disease (PD) is a neurodegenerative disease causing the loss of dopaminergic neurons in the substantia nigra, which chronically progresses [1]. Early PD patients undergoing medical treatment do not have significant difficulty in daily living, but patients with advanced PD experience difficulties in basic daily living activities due to various motor and non-motor symptoms, and the disability in daily living continually increases with progression of the disease [1,2]. Specific motor symptoms of PD, including bradykinesia, tremor, rigidity, and gait disturbance, are readily apparent to patients and caregivers, but their interests in and recognition of non-motor symptoms, including gastrointestinal symptoms, cognitive/emotional disorder, autonomic disturbance, and pain are lower [3]. In particular, the non-motor symptoms of PD have been identified as factors that increase burden of care and lower the quality of life more than the motor symptoms [4,5]. This finding has also been confirmed by a report showing that the non-motor symptoms may be the key factors that reduce the quality of life, even in early stages of the disease [6]. Therefore, proper understanding and recognition of the disease by PD patients and caregivers may be improved by providing more knowledge about the disease itself, and lack of understanding of the disease may have a negative effect on the care of PD patients [7,8].
            Jo Bowyer
            Chartered Physiotherapist Registered Osteopath.
            "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

            Comment


            • #66
              Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

              https://www.cell.com/neuron/fulltext...T+Newsletters=


              The Braak hypothesis posits that α-syn pathology can spread in a stereotyped fashion from the gastrointestinal tract via the vagus nerve to the ventral midbrain, where it selectively kills dopamine (DA) neurons of the substantia nigra pars compacta (SNc).
              Jo Bowyer
              Chartered Physiotherapist Registered Osteopath.
              "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

              Comment


              • #67
                Neuronal Parkinson inclusions are different than expected

                https://www.sciencedaily.com/release...0626124941.htm

                An international team of researchers challenges the conventional understanding of the cause of Parkinson's disease. The researchers have shown that the inclusions in the brain's neurons, characteristic of Parkinson's disease, are comprised of a membranous medley rather than protein fibrils.
                Jo Bowyer
                Chartered Physiotherapist Registered Osteopath.
                "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                Comment


                • #68
                  Caloric vestibular stimulation for the management of motor and non-motor symptoms in Parkinson's disease

                  https://www.prd-journal.com/article/...252-4/fulltext
                  Jo Bowyer
                  Chartered Physiotherapist Registered Osteopath.
                  "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                  Comment


                  • #69
                    Parkinson's disease may originate in the intestines

                    https://www.sciencedaily.com/release...0903105221.htm

                    "Parkinson's is a complex disease that we're still trying to understand. However, with this study and a similar study in the USA that has recently arrived at the same result using mice, the suspicion that the disease begins in the gut of some patients has gained considerable support."

                    The research project at Aarhus University also showed that the harmful alpha-synuclein not only travel from the intestines to the brain, but also to the heart.

                    "For many years, we have known that Parkinson patients have extensive damage to the nervous system of the heart, and that the damage occurs early on. We've just never been able to understand why. The present study shows that the heart is damaged very fast, even though the pathology started in the intestine, and we can continue to build on this knowledge in our coming research," says Per Borghammer.
                    Jo Bowyer
                    Chartered Physiotherapist Registered Osteopath.
                    "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                    Comment


                    • #70
                      The seeds of parkinson's disease: Amyloid fibrils that move through brain

                      https://www.sciencedaily.com/release...0903101457.htm

                      The researchers suggest that Parkinson's disease is a systemic (whole-body) amyloidosis rather than one that is localized to one part of the brain. This fits with the non-motor symptoms that patients experience before the onset of motor dysfunction and the multiple organ involvement of α-syn pathology. The findings from this work are highly applicable to the development of new diagnostic and therapeutic tools for the treatment of Parkinson's disease.​​​​​​​
                      Jo Bowyer
                      Chartered Physiotherapist Registered Osteopath.
                      "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                      Comment


                      • #71
                        Potential diagnostic tool, treatment for Parkinson's disease

                        https://www.sciencedaily.com/release...0926141734.htm

                        An age-related progressive movement disorder, the disease stems from the mysterious die-off of a set of nerve cells, or neurons, in the brain that fine-tunes bodily movement. These neurons, which originate in a midbrain structure, the substantia nigra, are referred to as dopaminergic because they secrete a substance, dopamine, to transmit motion-modulating signals to other neurons. By the time a person starts manifesting symptoms of the disease, an estimated 50% of the substantia nigra's dopaminergic neurons have already died.

                        What makes these particular neurons die is unknown. A leading theory holds that the special intensity with which they perform their duties frazzles their mitochondria. These bacteria-sized cellular components generate energy for cells in exchange for a steady supply of raw materials: oxygen and carbon-rich carbohydrates or fats.

                        This process, known as respiration, has a downside: It inevitably generates toxic byproducts called free radicals, which not only can cause cellular damage but are extremely harmful to the mitochondria themselves.

                        Parkinson's is known to involve a defect in mitochondrial function. The harder a cell has to work, the more energy its mitochondria have to churn out -- and the more likely they'll burn out. Dopaminergic neurons in the substantia nigra are among the body's hardest-working cells.

                        Mitochondria spend much of their time attached to a grid of protein "roads" that crisscross cells. Like old cars that can no longer pass a smog test because they can't stop spewing noxious exhaust fumes, defective mitochondria have to be taken off the road. Our cells have a technique for clearing mitochondrial clunkers: a series of proteins that shuffle them off to the cell's recycling centers. But first, those proteins have to remove an adaptor molecule called Miro that attaches mitochondria, damaged or healthy, to the grid.

                        Wang's group previously identified a mitochondrial-clearance defect in Parkinson's patients' cells: Their inability to remove Miro from damaged mitochondria.
                        Jo Bowyer
                        Chartered Physiotherapist Registered Osteopath.
                        "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                        Comment


                        • #72
                          Parkinson's disease is also present in the blood

                          https://www.sciencedaily.com/release...1003111747.htm
                          Jo Bowyer
                          Chartered Physiotherapist Registered Osteopath.
                          "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                          Comment


                          • #73
                            Self-reported and experimentally induced self-disgust is heightened in Parkinson’s disease: Contribution of behavioural symptoms

                            https://journals.plos.org/plosone/ar...l.pone.0223663

                            Parkinson’s disease (PD) is a neurodegenerative condition involving the dopaminergic neurons of the substantia nigra, classically characterised by motor symptoms [12]. However, a number of non-motor symptoms, such as depression, anxiety, sleep problems, and Impulse Control Disorders (ICDs), are now also recognised to be part of the condition [3]. In addition, over the last two decades there has been growing interest in emotional processes in PD, as a number of studies have reported emotional disturbances in the disorder [46]. Emotional disturbances in PD may not be too surprising given the looped architecture of the basal ganglia within which the substantia nigra pars compacta operates, and the clear identification of a limbic (emotional) loop within that architecture [7].
                            Jo Bowyer
                            Chartered Physiotherapist Registered Osteopath.
                            "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                            Comment


                            • #74
                              Increased use of antibiotics may predispose to Parkinson's disease

                              https://www.sciencedaily.com/release...1122113314.htm
                              Jo Bowyer
                              Chartered Physiotherapist Registered Osteopath.
                              "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                              Comment


                              • #75
                                Warning: Swimming and deep brain stimulation do not mix

                                https://www.statnews.com/2019/11/29/...ca00-151138121

                                “All of the patients in their series had dopaminergic reductions in medication greater than 50% post-surgery and it is possible that this factor may have played a large role in the decline in function,” he said. “Proper prospective testing of the device in the on- and off-medication condition, as well as in the pre- and post-operative testing conditions, will be required to sort out the root causes of this phenomenon. In the meantime, Parkinson’s patients with or without DBS should not swim without a buddy.”

                                Other complex motor behaviors, such as skiing, playing golf, or skating, might also be affected, Baumann said. But swimming is the most worrisome — not just for people with DBS, Okun warned.

                                “One important piece of advice for all Parkinson’s patients is to never swim alone,” Okun said. “The risk of medication wearing off and freezing has been known to be associated with drowning in Parkinson’s disease regardless of whether or not a deep brain stimulator has been implanted.”
                                ​​​​​​​
                                Jo Bowyer
                                Chartered Physiotherapist Registered Osteopath.
                                "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                                Comment

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