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Premotor Symptoms as Predictors of Outcome in Parkinsons Disease: A Case-Control Study

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  • #46
    Appendix Removal May Lower Parkinson’s Risk

    https://neurosciencenews.com/appendix-parkinsons-10128/

    “Our results point to the appendix as a site of origin for Parkinson’s and provide a path forward for devising new treatment strategies that leverage the gastrointestinal tract’s role in the development of the disease,” said Viviane Labrie, Ph.D., an assistant professor at Van Andel Research Institute (VARI) and senior author of the study. “Despite having a reputation as largely unnecessary, the appendix actually plays a major part in our immune systems, in regulating the makeup of our gut bacteria and now, as shown by our work, in Parkinson’s disease.”

    The reduced risk for Parkinson’s was only apparent when the appendix and the alpha-synuclein contained within it were removed early in life, years before the onset of Parkinson’s, suggesting that the appendix may be involved in disease initiation. Removal of the appendix after the disease process starts, however, had no effect on disease progression.
    Jo Bowyer
    Chartered Physiotherapist Registered Osteopath.
    "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

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    • #47
      Motor planning error in Parkinson's disease and its clinical correlates

      https://journals.plos.org/plosone/ar...l.pone.0202228

      Patients with Parkinson’s disease (PD) present with motor disorders, such as resting tremor, bradykinesia, rigidity, and postural instability [1], and other typical motor symptoms showing abnormal gait freezing gait, and motor coordination deficits [1, 2]. Some cognitive dysfunctions may be observed in addition to these motor symptoms. A representative cognitive dysfunction is decline in executive function, which is a part of frontal brain function and refers to the cognitive control of behavior: selecting and successfully monitoring behaviors that facilitate the attainment of chosen goals. Lezak has stated that executive function includes goal setting, motor planning, and effective motor execution [3]. Some previous studies reported that individuals with PD have decreased brain ability in the frontal lobe and striatum [4, 5], thus influencing their cognitive dysfunction [68].
      Jo Bowyer
      Chartered Physiotherapist Registered Osteopath.
      "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

      Comment


      • #48
        Cognition among individuals along a spectrum of increased risk for Parkinson’s disease

        https://journals.plos.org/plosone/ar...l.pone.0201964

        In Parkinson’s disease (PD), the second most common neurodegenerative disorder, motor symptoms constitute the core diagnostic criteria[1]. However, the pathophysiological changes of PD begin years to decades before clear-cut motor symptoms manifest[2]. These manifestations include a cluster of at-risk characteristics or prodromal manifestations. Therefore, the definition of PD has been extended to include individuals considered at-risk for PD. These fall along a broad spectrum of risk: asymptomatic carriers of mutations associated with PD, as well as individuals with prodromal non-motor clinical signs/symptoms, biomarker findings, or genetic polymorphisms that alone or in combination predict increased risk for PD to varying degrees[3].

        In many cases among individuals at-risk for PD, the course/progression to the motor manifestations of PD aligns well, both anatomically and temporally, with the neuropathological staging system proposed by Braak[4,5], as follows: (1) In Braak stage I, involvement of the olfactory tubercle and medulla manifests clinically with hyposmia (i.e., impaired olfaction), reduced heart rate variability, and other manifestations of autonomic dysfunction; (2) In Braak stage II, there is involvement of more rostral brainstem structures, including the serotonergic dorsal raphe nuclei, which clinically may manifest with anxiety and depression, and the glutamatergic peri-locus coeruleus, which has been hypothesized to lead to REM sleep behavior disorder [RBD]. Involvement of norepinephrine-producing neurons in the locus coeruleus at this stage may also mediate subtle abnormalities in cognition [e.g., attention and working memory] reported in the prodromal PD state[6].
        Jo Bowyer
        Chartered Physiotherapist Registered Osteopath.
        "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

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        • #49
          Road to cell death more clearly identified for Parkinson's disease

          https://www.sciencedaily.com/release...1102094823.htm
          Jo Bowyer
          Chartered Physiotherapist Registered Osteopath.
          "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

          Comment


          • #50
            Singing may reduce stress, improve motor function for people with Parkinson's disease

            https://www.sciencedaily.com/release...1107111853.htm

            The research builds upon the team's previous findings that singing is an effective treatment to improve respiratory control and the muscles used for swallowing in people with Parkinson's disease. The prevalence of Parkinson's disease is expected to double over the next 20 years. ISU researchers say therapeutic singing has the potential to provide an accessible and affordable treatment option to improve motor symptoms, stress and quality of life for people with Parkinson's disease.

            In this video from 2017, Stegemöller leads a singing group for people with Parkinson's disease: https://www.youtube.com/watch?v=HNmm3uvYo_c
            Jo Bowyer
            Chartered Physiotherapist Registered Osteopath.
            "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

            Comment

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