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Premotor Symptoms as Predictors of Outcome in Parkinsons Disease: A Case-Control Study

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  • #31
    Handwriting training in Parkinson’s disease: A trade-off between size, speed and fluency

    http://journals.plos.org/plosone/art...l.pone.0190223
    Jo Bowyer
    Chartered Physiotherapist Registered Osteopath.
    "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

    Comment


    • #32
      Effects of physical exercise programs on cognitive function in Parkinson’s disease patients: A systematic review of randomized controlled trials of the last 10 years

      http://journals.plos.org/plosone/art...l.pone.0193113
      Jo Bowyer
      Chartered Physiotherapist Registered Osteopath.
      "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

      Comment


      • #33
        Depression in Parkinson's disease: A case-control study

        http://journals.plos.org/plosone/art...l.pone.0192050

        Jo Bowyer
        Chartered Physiotherapist Registered Osteopath.
        "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

        Comment


        • #34
          The effects of anxiety and external attentional focus on postural control in patients with Parkinson's disease

          The results of the current study provide evidence that anxiety influences balance control and postural stability in patients with PD, particularly those with high levels of anxiety. The results also confirmed that external focus is a potential strategy that significantly improves the postural control of these patients. Further investigation of clinical applicability is warranted towards developing effective therapeutic and rehabilitative treatment plans.
          Jo Bowyer
          Chartered Physiotherapist Registered Osteopath.
          "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

          Comment


          • #35
            Common Anti-Inflammatory Therapy May Reduce Parkinson’s Risk

            http://neurosciencenews.com/parkinso...ammatory-8873/

            The recent study, published in JAMA Neurology, shows that individuals with IBD are at a 28% higher risk of developing Parkinson’s disease than those without IBD. However, if they are treated with anti-Tumor Necrosis Factor alpha (anti-TNFα) therapy, a monoclonal antibody that is commonly used to control inflammation in IBD patients, then their risk of developing Parkinson’s disease goes down significantly, and becomes even lower than that in the general population.

            These new insights will allow for better screening of IBD patients for Parkinson’s disease, given that IBD onset usually precedes that of Parkinson’s disease by decades, and they also offer evidence to support exploring anti-TNFα therapy to prevent Parkinson’s disease in at-risk individuals.
            Jo Bowyer
            Chartered Physiotherapist Registered Osteopath.
            "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

            Comment


            • #36
              Eating More Fish Could Prevent Parkinson’s

              http://neurosciencenews.com/parkinsons-fish-8861/
              Jo Bowyer
              Chartered Physiotherapist Registered Osteopath.
              "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

              Comment


              • #37
                Abnormal gait pattern emerges during curved trajectories in high-functioning Parkinsonian patients walking in line at normal speed

                http://journals.plos.org/plosone/art...l.pone.0197264
                Jo Bowyer
                Chartered Physiotherapist Registered Osteopath.
                "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                Comment


                • #38
                  Cognitive Training Reduces Gait Freezing in Parkinson’s

                  http://neurosciencenews.com/gait-fre...training-9085/
                  Jo Bowyer
                  Chartered Physiotherapist Registered Osteopath.
                  "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                  Comment


                  • #39
                    Sleep problems in Parkinson's disease: Can we fix them?

                    https://www.sciencedaily.com/release...0607135154.htm
                    Jo Bowyer
                    Chartered Physiotherapist Registered Osteopath.
                    "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                    Comment


                    • #40
                      A new way to examine stress and inflammation in the heart will help Parkinson’s researchers test new therapies and explore an unappreciated way the disease puts people at risk of falls and hospitalization.

                      https://neurosciencenews.com/parkins...t-damage-9568/


                      By the time Parkinson’s disease patients are diagnosed — typically based on the tremors and motor-control symptoms most associated with the disease — about 60 percent of them also have serious damage to the heart’s connections to the sympathetic nervous system. When healthy, those nerves spur the heart to accelerate its pumping to match quick changes in activity and blood pressure.

                      “This neural degeneration in the heart means patients’ bodies are less prepared to respond to stress and to simple changes like standing up,” says Marina Emborg, a University of Wisconsin-Madison professor of medical physics and Parkinson’s researcher at the Wisconsin National Primate Research Center. “They have increased risk for fatigue, fainting and falling that can cause injury and complicate other symptoms of the disease.”
                      Jo Bowyer
                      Chartered Physiotherapist Registered Osteopath.
                      "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                      Comment


                      • #41
                        Traffic Jams in the Brain

                        https://neurosciencenews.com/parkins...ruptions-9615/
                        Jo Bowyer
                        Chartered Physiotherapist Registered Osteopath.
                        "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                        Comment


                        • #42
                          Motor planning error in Parkinson's disease and its clinical correlates

                          http://journals.plos.org/plosone/art...l.pone.0202228



                          Patients with Parkinson’s disease (PD) present with motor disorders, such as resting tremor, bradykinesia, rigidity, and postural instability [1], and other typical motor symptoms showing abnormal gait freezing gait, and motor coordination deficits [1, 2]. Some cognitive dysfunctions may be observed in addition to these motor symptoms. A representative cognitive dysfunction is decline in executive function, which is a part of frontal brain function and refers to the cognitive control of behavior: selecting and successfully monitoring behaviors that facilitate the attainment of chosen goals. Lezak has stated that executive function includes goal setting, motor planning, and effective motor execution [3]. Some previous studies reported that individuals with PD have decreased brain ability in the frontal lobe and striatum [4, 5], thus influencing their cognitive dysfunction [68].

                          In the present study, we focused on the executive function of motor prediction based on working memory and motor-related strategic thinking. In a previous study, although movement accuracy did not decline, they prolonged the time until movement by using the Tower of London task [9]. Based on the results, patients with PD have been suggested to have difficulty in the motor prediction of operating figures [9]. Furthermore, Owen et al. then focused on severe PD in the investigation of decreased motor prediction and reported that patients with severe PD particularly had a difficulty in motor execution accuracy of the task in addition to motor prediction delay [10]. These results suggested that severity of PD affected motor prediction and function.

                          The effects of motor prediction disorder in patients with PD are shown not only in operation of figures but also in action imitation tasks. For example, using apraxia testing, Goldenberg et al. have reported that patients with PD had impaired ability of action imitation [11]. These previous studies have shown that patients with PD had difficulty in motor prediction by using executive function.

                          Difficulty of motor prediction affect some actual movement disabilities. Cohen et al. reported that patients with PD frequently made a judgment error on whether they could pass an aperture without collisions. This result showed the difficulty of motor prediction in patients with PD, indicating that the judgment error would result in freezing gait [12]. Kameda et al. measured the amounts of discordance between motor prediction and motor execution of forward reach distance (functional reach distance), reporting that overestimation (prediction distance > actual distance) leads to a high frequency of falls in patients with PD [13]. Through these studies, movement disabilities in patients with PD have been suggested to be related to motor prediction error, including motor-related overestimation.

                          However, whether a factor is associated with motor prediction error is still unclear. Identification of the factor associated with motor prediction error would contribute in the determination of the mechanisms of movement disability (freezing gait or falling) directly affecting activity of daily living. In the present study, we used a two-step test to measure motor prediction error [14]. The reliability of the two-step test, which was developed to judge the requirement of nursing care in Japan, or being at risk of doing so, due to a decline in mobility, resulting from a musculoskeletal system disorder, has been confirmed [14]. Subsequently, we investigated whether motor prediction was related to the factors of PD (severity, duration, cognitive function, or motor function).
                          Jo Bowyer
                          Chartered Physiotherapist Registered Osteopath.
                          "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                          Comment


                          • #43
                            Novel Brain Network Linked to Chronic Pain in Parkinson’s

                            https://neurosciencenews.com/chronic...-network-9761/
                            Jo Bowyer
                            Chartered Physiotherapist Registered Osteopath.
                            "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                            Comment


                            • #44
                              Eradicating Helicobacter pylori infections may be a key treatment for Parkinson's disease

                              https://www.sciencedaily.com/release...0924105749.htm

                              While human genetic mutations are involved in a small number of Parkinson's disease (PD) cases, the vast majority of cases are of unknown environmental causes, prompting enormous interest in identifying environmental risk factors involved. The link between Helicobacter pylori (H. pylori) and gastric ulcers has been known for several decades, but new evidence suggests that this harmful bacterium may play a role in PD as well. A new review in the Journal of Parkinson's Diseasesummarizes the current literature regarding the link between H. pylori and PD and explores the possible mechanisms behind the association.
                              Jo Bowyer
                              Chartered Physiotherapist Registered Osteopath.
                              "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                              Comment


                              • #45
                                Researchers Unexpectedly Reprogram Mature Neurons in Mice


                                https://neurosciencenews.com/mature-...program-10006/

                                The study, published today in Stem Cell Reports, reveals the possibility of changing mature neurons from one kind to another without relying on stem cells, contrary to the prevailing view.

                                The mouse study indicates that the brain’s neurons are more changeable in adulthood than previously thought, said corresponding author Dr. Chun-Li Zhang, Professor of Molecular Biology at UT Southwestern Medical Center. The long-held belief was that a neuron’s identity was sealed well before adulthood and that one kind of neuron could not morph into another variety, he added.
                                ​​​​​​​
                                Jo Bowyer
                                Chartered Physiotherapist Registered Osteopath.
                                "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                                Comment

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