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  • Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

    https://elifesciences.org/articles/39856

    Many factors beside genetics influence how long a person will live and our lifespan cannot be read from our DNA alone. Nevertheless, Timmers et al. had hoped to narrow down their search and discover specific genes that directly influence how quickly people age, beyond diseases. If such genes exist, their effects were too small to be detected in this study. The next step will be to expand the study to include more participants, which will hopefully pinpoint further genomic regions and help disentangle the biology of ageing and disease.
    This paper has been trending in the UK and not only in the medical and scientific press. Care of the elderly has been a particular interest of mine since I was a junior physiotherapist. As a family practitioner I see patients who started with me in the prime of life and are now in their eighties and nineties, I have one or two who are in severe denial with regards to cognitive change, they have supportive family members, but will not take advice from them and get into difficulties with regards to risk taking behaviour. Persuading some elders that they should stop driving can be particularly difficult and many families leave it until the elderly relative has crashed a car. Planning quality of life in extreme old age should start while the person is still young.
    Jo Bowyer
    Chartered Physiotherapist Registered Osteopath.
    "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

    Comment


    • Blood Test Detects Alzheimer’s Damage Before Symptoms

      https://neurosciencenews.com/alzheim...od-test-10596/
      Jo Bowyer
      Chartered Physiotherapist Registered Osteopath.
      "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

      Comment


      • Signs of Memory Problems May Instead Be Symptoms of Hearing Loss

        https://neurosciencenews.com/hearing-memory-10606/

        “We commonly see clients who are worried about Alzheimer’s disease because their partner complains that they don’t seem to pay attention, they don’t seem to listen or they don’t remember what is said to them,” says Dr. Vandermorris. “Sometimes addressing hearing loss may mitigate or fix what looks like a memory issue. An individual isn’t going to remember something said to them if they didn’t hear it properly.”
        Jo Bowyer
        Chartered Physiotherapist Registered Osteopath.
        "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

        Comment


        • New science details discovery of bacterial pathogen in brains of Alzheimer's patients

          https://www.sciencedaily.com/release...0123165002.htm

          New science uncovers how an unlikely culprit, Porphyromonas gingivalis (Pg) -- the bacterium commonly associated with chronic gum disease -- appears to drive Alzheimer's disease (AD) pathology.
          Jo Bowyer
          Chartered Physiotherapist Registered Osteopath.
          "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

          Comment


        • Those with inadequate access to food likely to suffer from obesity

          https://www.sciencedaily.com/release...0123144522.htm

          It sounds like a contradiction in terms, but fresh fruit and vegetables can be expensive and many survive on ready meals.
          Jo Bowyer
          Chartered Physiotherapist Registered Osteopath.
          "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

          Comment


          • Effects of Nordic walking training on quality of life, balance and functional mobility in elderly: A randomized clinical trial

            https://journals.plos.org/plosone/ar...l.pone.0211472

            The hypothesis was not supported, our findings indicated that after 8 weeks, the Nordic walking training did not result in greater improvements than free walking training for the primary outcome (self-selected walking speed) and most of the secondary outcomes (including locomotor rehabilitation index, static balance, dynamic stability, and psychological and social participation domains of quality of life).
            Jo Bowyer
            Chartered Physiotherapist Registered Osteopath.
            "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

            Comment


            • Objective measures of rollator user stability and device loading during different walking scenarios

              https://journals.plos.org/plosone/ar...l.pone.0210960
              Jo Bowyer
              Chartered Physiotherapist Registered Osteopath.
              "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

              Comment


              • A study reveals that a large part of the population is not able to breathe properly

                https://www.sciencedaily.com/release...0204172244.htm
                Jo Bowyer
                Chartered Physiotherapist Registered Osteopath.
                "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                Comment


                • A new culprit in cognitive decline in Alzheimer's disease

                  https://www.sciencedaily.com/release...0205115419.htm

                  In their study, published in the scientific journal Neuron, the researchers found that fibrinogen, after leaking from the blood into the brain, activates the brain's immune cells and triggers them to destroy important connections between neurons. These connections, called synapses, are critical for neurons to communicate with one another.

                  Previous studies have shown that elimination of synapses causes memory loss, a common feature in Alzheimer's disease and other dementias. Indeed, the scientists showed that preventing fibrinogen from activating the brain's immune cells protected mouse models of Alzheimer's disease from memory loss.

                  "We found that blood leaks in the brain can cause elimination of neuronal connections that are important for memory functions," explains Akassoglou, who is also a professor of neurology at UC San Francisco (UCSF). "This could change the way we think about the cause and possible cure of cognitive decline in Alzheimer's disease and other neurological diseases."

                  The team showed that fibrinogen can have this effect even in brains that lack amyloid plaques, which are the focus of diverse treatment strategies that have failed in large clinical trials. The researchers showed that injecting even extremely small quantities of fibrinogen into a healthy brain caused the same kind of immune cell activation and loss of synapses they saw in Alzheimer's disease.
                  Jo Bowyer
                  Chartered Physiotherapist Registered Osteopath.
                  "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                  Comment


                  • How exercise may protect against Alzheimer's

                    https://www.sciencedaily.com/release...0208173511.htm

                    A few years ago, exercise researchers discovered a hormone called irisin that is released into the circulation during physical activity. Initial studies suggested that irisin mainly played a role in energy metabolism. But newer research found that the hormone may also promote neuronal growth in the brain's hippocampus, a region critical for learning and memory.

                    "This raised the possibility that irisin may help explain why physical activity improves memory and seems to play a protective role in brain disorders such as Alzheimer's disease" says Arancio, who is a professor of pathology and cell biology and of medicine at Columbia University Vagelos College of Physicians and Surgeons.
                    Jo Bowyer
                    Chartered Physiotherapist Registered Osteopath.
                    "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                    Comment


                    • Accelerated risk of mobility loss for people aged 60+ tied to excess weight/inactivity

                      https://www.sciencedaily.com/release...0212104731.htm
                      Jo Bowyer
                      Chartered Physiotherapist Registered Osteopath.
                      "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                      Comment


                      • ‘Lack of Cleaning’ in Brain Cells is Central to Alzheimer’s

                        https://neurosciencenews.com/mitocho...heimers-10744/
                        Last edited by Jo Bowyer; Yesterday, 04:15 PM.
                        Jo Bowyer
                        Chartered Physiotherapist Registered Osteopath.
                        "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                        Comment


                        • Exercise prevents falls in older people – but will any type of exercise do?

                          http://www.evidentlycochrane.net/exe...revents-falls/

                          Jo Bowyer
                          Chartered Physiotherapist Registered Osteopath.
                          "Out beyond ideas of wrongdoing and rightdoing,there is a field. I'll meet you there." Rumi

                          Comment

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