Mechanosensation

[Diane]

I'm starting a new place to collect articles on mechanosensation.
1. GM. Ransil BJ. Lin HC. Leem JG. Inflammation induces ectopic mechanical sensitivity in axons of nociceptors innervating deep tissues. Journal of Neurophysiology. 90(3):1949-55, 2003. (http://jn.physiology.org/cgi/content/full/90/3/1949) (full text)
2. Quintner JL. Bove GM. From neuralgia to peripheral neuropathic pain: evolution of a concept. Regional Anesthesia & Pain Medicine. 26(4):368-72, 2001. (http://www.mdconsult.com/das/article/body/82245560-2/jorg=journal&source=&sp=11990306&sid=0/N/245289/1.html) (abstract only) Link to the article (http://www.somasimple.com/forums/showthread.php?p=42152#post42152)

[Diane]

Auton Neurosci. 2007 Oct 30;136(1-2):96-9. Epub 2007 May 15.

Contribution of supraspinal and spinal structures to the responses of dorsal spinal cord blood flow to innocuous cutaneous brushing in rats.
Kurosawa M, Toda H, Watanabe O, Budgell B.


Responses of dorsal spinal cord blood flow (SCBF) to innocuous mechanical cutaneous stimulation were investigated in anesthetized central nervous system intact (CNS-intact) and C2 spinalized rats. SCBF was recorded at the L4-L6 level with a laser Doppler flowmeter. SCBF increased with brushing of the ipsilateral proximal hindlimb and hindpaw, and there were no significant differences in the magnitudes of the responses in CNS-intact and spinalized animals. Brushing of the lower back had no effect on SCBF at the L4-L6 level in either cohort. Brushing stimulation produced no significant changes in systemic arterial blood pressure. The responses of SCBF to brushing in CNS-intact animals were diminished by pretreatment with phenoxybenzamine, an alpha-adrenoceptor blocking agent, but no such effects were seen in spinalized animals. These results indicate that innocuous mechanical cutaneous input can produce a segmentally-organized increase in regional SCBF, and that the responses are modulated, in part at least, by alpha-adrenergic receptors via supraspinal structures.

PMID: 17507293

[Jason Silvernail]

Diane-
Hope these help, too.

[Diane]

Thanks for adding these Jason.