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Jon Newman
08-08-2007, 08:15 PM
I recently read this interesting commentary by Nathaniel Katz in The Clinical Journal of Pain

Here's the reference:

Clin J Pain. 2007 May;23(4):303-6. Links
Opioids: after thousands of years, still getting to know you.

Katz N.
Analgesic Research, Needham, MA 02494, USA. nkatz@analgesicresearch.com
PMID: 17449990 He begins:

The use of opioids for chronic pain has been evident throughout the millenia of recorded history, even while opinions about the use of opioids for chronic pain have fluctuated, like a pendulum, from one extreme to the another. The preserved remains of cultivated poppy seeds and pods have been discovered in sites of Neolithic dwellings in Switzerland, dating from the fourth millennium BC. The first human writing, from Sumeria around 2400 BC, used ideograms representing the poppy, translated as the "joy plant."He points out that

Prescription opioid abuse is the second largest type of illicit drug abuse, second only to marijuana, and ahead of cocaine and heroin. New initiates to illicit drug use now report prescription opioids as the first drug they try (2.1 million in 2005), ahead of marijuana, and nearly equal to the number of new inititates to smoking (2.3 million). Deaths related to prescription opioids continue to rise year after year at an alarming rate. About one in ten 12th graders has tried a prescription opioid nonmedically. Of the approximately 1.3 million suicide attempts per year by adolenscents, about one-half involve pain relievers.But this is the paragraph that hooked me

Why has the opinion of the world's leading experts on opioid therapy fluctuated so dramatically from century to century for thousands of years without any sign of settling into an evidence-based consensus? One likely cause is the absence of systematically acquired and soberly interpreted data on the important questions relevant to long-term opioid therapy. Without the anchor of data, experts are free to opine based on the vagaries of their prersonal experience. One would think that in this era of evidence-based medicine, one could simply turn to the clinical research literature on opioids and find answers to the most pressing questions about long-term opioid therpary. After all, pain is the most common complaint leading a patient to a physician. Including lost work productivity, pain may be the most costliest disease in the United States. Opioids are the most common medications prescribed by doctors in the United States.And finally, this "say what?" fact

Remarkably, the first RPCT of opioids for chronic pain did not appear until the mid 1990's, and the entirety of this body of RPCT literature appeared as if by magic in less than a decade.RPCT means "randomized placebo controlled trial"

While I find myself pondering numerous things the two that I'll encourage some conversation about here are:

1. Is it helpful to consider pain as a disease as mentioned by the author? I'm not sure if this stood out to anyone as they read it but it did to me.

2. Second are the author's comments about...well let me restate them

One likely cause is the absence of systematically acquired and soberly interpreted data on the important questions relevant to long-term opioid therapy.How does one go about soberly interpreting data? I'm assuming one doesn't literally have to be sober at the time.

Oh, the important questions raised by the author include:

Are opioids efficacious for chronic pain?How effective are opioids in the long run?What proportion of patients prescribed opioids become addicted? Can they be identified early before problems get out of hand?Is opioid prescribing a driver of prescription opioid abuse, or can be rest assured that our patients rarely develop abuse-related problems?What proportion of patients develop tolerance, so that the medication loses its usefulness over time? Do side effects get better over time?

Jon Newman
18-08-2007, 05:18 AM
New initiates to illicit drug use now report prescription opioids as the first drug they try (2.1 million in 2005), ahead of marijuana, and nearly equal to the number of new inititates to smoking (2.3 million).

It just occurs to me that alcohol likely wasn't considered in this analysis.

Check this out (http://scienceblogs.com/mikethemadbiologist/2007/08/our_kids_are_booze_hounds.php).

nari
18-08-2007, 06:19 AM
One day the powers-to-be will wake up to the fact that alcohol causes more mortality and morbidity, as well as violence, than smoking ever did or could.
Here, we are just starting to look at the damage done by alcohol, particularly teenagers'brains and other people's. Hospital admissions for ETOH-related conditions are steadily on the rise, according to hospital stats here.

Mind you, I like my grog.


Nari

Jon Newman
23-08-2007, 05:57 AM
I look forward to the published work of Daniel Goldberg based on this recent entry on the MHB (http://www.medhumanities.org/2007/08/on-increasing-o.html)

Jon Newman
07-06-2008, 06:27 AM
Post-op pain management in the chronic opioid user can be a challenging problem in the acute care setting. This article (http://www.molecularpain.com/content/4/1/7) (pdf available at bottom of this post) had some interesting insights that the anesthesiologists/surgeons at your hospital may be interested in following. While there are no clear practice suggestions this line of research is at least promising to those concerned about pain relief in the chronic opioid user.

On a side note, I found their method of testing nociceptive thresholds in mice informative:

Mechanical allodynia was assayed using nylon von Frey filaments according to the "up-down" algorithm described by Chaplan et al. [61 (http://www.molecularpain.com/content/4/1/7#B61)] as we have used previously to detect allodynia in mice [36 (http://www.molecularpain.com/content/4/1/7#B36),62 (http://www.molecularpain.com/content/4/1/7#B62),63 (http://www.molecularpain.com/content/4/1/7#B63)]. In these experiments mice were placed on wire mesh platforms in clear cylindrical plastic enclosures 10 cm in diameter and 40 cm in height. After 15 minutes of acclimation, fibers of sequentially increasing stiffness were applied 1 mm lateral to the central wound edge, pressed upward to cause a slight bend in the fiber and left in place 5 sec. Withdrawal of the hind paw from the fiber was scored as a response. When no response was obtained the next stiffest fiber in the series was applied to the same paw; if a response was obtained a less stiff fiber was applied. Testing proceeded in this manner until 4 fibers had been applied after the first one causing a withdrawal response allowing the estimation of the mechanical withdrawal threshold [64 (http://www.molecularpain.com/content/4/1/7#B64)]. This data fitting algorithm allowed the use of parametric statistics for analysis. This assay is sufficiently sensitive to detect mechanical thresholds as low as 0.02 g [21 (http://www.molecularpain.com/content/4/1/7#B21)].

I also noted a quick reference to chronic low back pain:

More recently it was shown that chronic back pain sufferers develop measurable hyperalgesia after only one month of opioid administration [12 (http://www.molecularpain.com/content/4/1/7#B12)].

Here's the citation/abstract referenced in that quote

J Pain. (javascript:AL_get(this, 'jour', 'J Pain.');) 2006 Jan;7(1):43-8.
Related Articles (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=16414554&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract), Links (javascript:PopUpMenu2_Set(Menu16414554);)
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif (http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=Abstract-def&uid=16414554&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S1526-5900%2805%2900826-6)
Opioid tolerance and hyperalgesia in chronic pain patients after one month of oral morphine therapy: a preliminary prospective study.

Chu LF (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Chu%20LF%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract), Clark DJ (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Clark%20DJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract), Angst MS (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Angst%20MS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract).

Department of Anesthesia, Stanford University School of Medicine, CA 94305, USA.

There is accumulating evidence that opioid therapy might not only be associated with the development of tolerance but also with an increased sensitivity to pain, a condition referred to as opioid-induced hyperalgesia (OIH). However, there are no prospective studies documenting the development of opioid tolerance or OIH in patients with chronic pain. This preliminary study in 6 patients with chronic low back pain prospectively evaluated the development of tolerance and OIH. Patients were assessed before and 1 month after initiating oral morphine therapy. The cold pressor test and experimental heat pain were used to measure pain sensitivity before and during a target-controlled infusion with the short-acting mu opioid agonist remifentanil. In the cold pressor test, all patients became hyperalgesic as well as tolerant after 1 month of oral morphine therapy. In a model of heat pain, patients exhibited no hyperalgesia, although tolerance could not be evaluated. These results provide the first prospective evidence for the development of analgesic tolerance and OIH by using experimental pain in patients with chronic back pain. This study also validated methodology for prospectively studying these phenomena in larger populations of pain patients. PERSPECTIVE: Experimental evidence suggests that opioid tolerance and opioid-induced hyperalgesia might limit the clinical utility of opioids in controlling chronic pain. This study validates a pharmacologic approach to study these phenomena prospectively in chronic pain patients and suggests that both conditions do occur within 1 month of initiating opioid therapy.

Jon Newman
13-06-2008, 03:09 PM
This thread slipped my mind when I started this one (http://www.somasimple.com/forums/showthread.php?t=5653).

Also, looking back at the start of this thread, I posed this snarky question and comment:

One likely cause is the absence of systematically acquired and soberly interpreted data on the important questions relevant to long-term opioid therapy.--Katz

How does one go about soberly interpreting data? I'm assuming one doesn't literally have to be sober at the time.--NewmanI'm going to perform a snarkectomy and re-ask the question. How DOES one go about soberly interpreting data? It seems to me that interpretation requires some theory. Or at least a story.

Mary C
14-06-2008, 02:21 AM
"This thread slipped my mind when I started this one (http://www.somasimple.com/forums/showthread.php?t=5653)."

How about combining them? The info on chronic morphine use was eye-opening for me. Thanks.

Jon Newman
14-06-2008, 03:42 AM
I hesitated to merge the threads because I haven't had much luck making the merge happen in a sensible manner and the thread I linked to (the one in your quote) only contained the one post. Having said that, I took your suggestion. Post number 5 represents the merged thread. Now if you click on the link called "this one" it will link to this same thread which may confuse people and I don't need any help in that department.

I guess I'm not much for merging threads but I'm leaving it.