14 November, 2008
Volume 135, Issue 4

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Volume 135, Issue 4

On the cover: The many words “Cell” represent cells in a heterogeneous tissue, in this case the many different cell types in the brain. The green “Cell” represents the cell-specific labeling of translated mRNAs made possible by the translating ribosome affinity purification (TRAP) technique reported in this issue by Heiman et al. (pp. 738–748). This technique is applied by Doyle et al. (pp. 749–762) to molecularly characterize specific cell populations in the brain. Conceptual design by Myriam and Maxwell Heiman, artwork by Andrew Tang.

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cdc7 mutants fail to undergo nuclear division in meiosis I but segregate sister chromatids on a single spindle axis in meiosis II
Meiosis in a wild-type (left) and a cdc7 mutant cell (right). Tubulin and the Cdc14 phosphatase (marked with an asterisk) are shown in green, and the nucleus is shown in red. Initially, Cdc14 is confined to the nucleolus but is transiently released into the nucleoplasm during anaphase of both meiosis I and II. The cdc7 mutant fails to undergo nuclear division during the first Cdc14 release but segregates sister chromatids on a single spindle axis during the second release. See also paper by Matos et al..

SnapShots

 

 SnapShots present up-to-date tables of nomenclature and glossaries, full signaling pathways, and schematic diagrams of cellular processes. Click here, for a full list of SnapShots.

 

SnapShot: Cell-Cycle Regulators I
David O. Morgan

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In this Issue

The effects of telomerase in organismal aging
DnaA and DnaC spiral into DNA replication initiation
Pol V transcription induces silencing
H2A histone variant pairs up with Polycomb in ES cells
DDK ramps up for meiosis
Signaling antibiotic cell death by two components
Bacteria beat back bleach with Hsp33
TCR tyrosines hide out in the membrane
ART proteins clean up the cell surface
A cooperative green beard gene in yeast
TRAPing neuronal subtypes in the CNS: Heiman et al. and Doyle et al.

Immediate Early Publication

Real-Time Redox Measurements during Endoplasmic Reticulum Stress Reveal Interlinked Protein Folding Functions
Philip I. Merksamer, Ala Trusina, and Feroz R. Papa

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer
Lars Zender, Wen Xue, Johannes Zuber, Camile P. Semighini, Alexander Krasnitz, Beicong Ma, Peggy Zender, Stefan Kubicka, John M. Luk, Peter Schirmacher, W. Richard McCombie, Michael Wigler, James Hicks, Gregory J. Hannon, Scott Powers, and Scott W. Lowe

Featured Article

Featured articles are freely available to all readers

 
Immune receptors signal through cytoplasmic tyrosine-based motifs (ITAMs) and are regulated by tyrosine-phosphorylation. Xu et al. now show that prior to receptor activation, key tyrosines in the ITAM located in the CD3ε cytoplasmic domain of the T cell receptor insert into the hydrophobic core of the lipid bilayer, rendering them inaccessible to kinases.
Dr. Fabiola Rivas speaks with Dr. Kai Wucherpfennig about activation of immune receptors and his recent findings showing that a key signaling motif in the CD3ε cytoplasmic domain of the T cell receptor is membrane bound prior to receptor activation.

Dr. Kai Wucherpfennig

Leading Edge Featured Article

In this Minireview, Tamaki Suganuma and Jerry Workman discuss recent insights into how histone modifications talk to each other to fine tune regulation of gene expression.

Crosstalk among Histone Modifications
Tamaki Suganuma and Jerry L. Workman

Cell PaperClips

Dr. Michael Ehlers Myosin Vb Mobilizes Recycling Endosomes and AMPA Receptors for Postsynaptic Plasticity
In this PaperClip, Dr. Elena Porro speaks with Dr. Michael Ehlers about studying the cell biology of neurons and about the findings reported in his paper identifying a myosin motor protein that senses calcium and moves AMPA Receptor-containing recycling endosomes into dendritic spines during LTP.

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Cell Podcast

 
In our latest podcast, we hear from Dr. Gokhan Hotamisligil about a new lipid hormone produced by fat that might help to keep you thin. We learn from Dr Ralph Steinman, who discovered dendritic cells 35 years ago, about using these elusive cells to make better vaccines.

We also hear from Dr Elizabeth Phelps about regions of the brain that control responses to fearful memories. Finally, stay tuned for our quarterly roundup of exciting research highlights published in the Cell Press family of journals.

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